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Thank you for submitting your work entitled "Phenotypic plasticity as an adaptation to a functional trade-off" for consideration by eLife . Your article has been reviewed by four peer reviewers (including the Reviewing Editor) and Ian Baldwin as the Senior Editor.

Our decision has been reached after consultation between the reviewers. Based on these discussions and the individual reviews below, we feel that the message is interesting, but it may take you more than 2 months to fix all problems. Our main concerns are in how you performed and interpreted experiments, and in the mathematical model. Thus, we regret to inform you that we reject your submission at its current stage. However, if you can address all our concerns, eLife will be happy to consider a re-submission.

Reviewer #1:

The manuscript by Yi and Dean showed that phenotypic plasticity can evolve to break a functional trade-off between growth and chemotaxis. The manuscript started with a model prediction on how bacteria exposed to fluctuating environment and selection (selecting for growth following by selecting for chemotaxis) should evolve. Indeed, such prediction was shown to hold for early stage of evolution where cells initially evolved to be better at both growth and chemotaxis (my interpretation here differs somewhat from that of authors) and at phase 2 evolved along a Pareto front as cells evolved to be slower grower and faster swimmer. At phase 3 (P3), a single mutation in fliA allowed cells to break this tradeoff. fliA mutant lowered swimming speed during exponential growth when chemotaxis is not selected for, and increased swimming speed and fraction of motile cells at high cell density. The results are interesting. However, major issued will need to be addressed before acceptance.

1) I am not sure that I understand the lack of reproducibility across figures. Figure 2B shows that ancestor at 0 hr has a swimming speed of 8 μm/s. In Citra Dress in Coral Diane Von Fürstenberg Sale Best Seller f0RQ9q3CM
, fraction motile in ancestor is close to 0, and the swimming speed is only ~2 8 μm/s ( Figure 3B ). This type of several-fold difference makes me suspicious.

2) Even though mutation in filA does seem to have an effect since fliA mutation is sufficient to increase swimming speed and% motile cells during late stage growth ( Clearance Big Sale Denimflex Dark Wash Jegging With No Front Pockets Maurices Discount Eastbay Shopping Online ApcLVjyC
), some other mutation(s) in P3 can also yield the same phenotype (compare late stage growth of solid red in distressed detail jeans Blue Offwhite Cheap Sale Outlet Store r0OVD
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). My hypothesis is further supposed by the observation that in Figure 2B , the red line seems to show a much more drastic phenotype during early stages than the fliA mutant.

3) The writing is often confusing. For example, Figure 1A makes one believe that they are doing experiments, but Givenchy 2017 Bomber Jacket Quality Cheap Sale Sale Outlet Order Vh6My
give the impression of modeling. They do not lay out their model clearly (especially in the fifth paragraph of the main text where chemotaxis enters the game). Note that fitness (growth rate) can be quantified since it is constant during exponential phase. However, for chemotaxis, does population ratio change exponentially over time? In other words, would you get very different results if the duration of chemotaxis assay varies?

For example, this privilege authorizes a user to run the following command which executes a find command on a collection with the given UUID. In order to be successful, this operation also requires that the user is authorized to execute the find command on the collection namespace corresponding to the given UUID.

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Shortcut for postcircumfix { } that quotes its argument using the same rules as the interpolating quote-words operator of the same name.

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The operator for calling one method, $invocant.method .

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A mutating method call . $invocant.=method desugars to $invocant = $invocant.method , similar to .

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