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Thank you for submitting your work entitled "Phenotypic plasticity as an adaptation to a functional trade-off" for consideration by eLife . Your article has been reviewed by four peer reviewers (including the Reviewing Editor) and Ian Baldwin as the Senior Editor.

Our decision has been reached after consultation between the reviewers. Based on these discussions and the individual reviews below, we feel that the message is interesting, but it may take you more than 2 months to fix all problems. Our main concerns are in how you performed and interpreted experiments, and in the mathematical model. Thus, we regret to inform you that we reject your submission at its current stage. However, if you can address all our concerns, eLife will be happy to consider a re-submission.

Reviewer #1:

The manuscript by Yi and Dean showed that phenotypic plasticity can evolve to break a functional trade-off between growth and chemotaxis. The manuscript started with a model prediction on how bacteria exposed to fluctuating environment and selection (selecting for growth following by selecting for chemotaxis) should evolve. Indeed, such prediction was shown to hold for early stage of evolution where cells initially evolved to be better at both growth and chemotaxis (my interpretation here differs somewhat from that of authors) and at phase 2 evolved along a Pareto front as cells evolved to be slower grower and faster swimmer. At phase 3 (P3), a single mutation in fliA allowed cells to break this tradeoff. fliA mutant lowered swimming speed during exponential growth when chemotaxis is not selected for, and increased swimming speed and fraction of motile cells at high cell density. The results are interesting. However, major issued will need to be addressed before acceptance.

1) I am not sure that I understand the lack of reproducibility across figures. Buy Cheap Good Selling belted dress Red Sportmax Free Shipping 100% Original Kiuvz7xpN
shows that ancestor at 0 hr has a swimming speed of 8 μm/s. In Herve Leger Alyse ALine Dress Enjoy Online Factory Outlet Sale Online Sale Very Cheap Kxxvh
, fraction motile in ancestor is close to 0, and the swimming speed is only ~2 8 μm/s ( Balenciaga HighRise Crop Pants Outlet Sale Cheap Discounts Finishline Cheap Price Hot Sale Online qQQ2FH
). This type of several-fold difference makes me suspicious.

2) Even though mutation in filA does seem to have an effect since fliA mutation is sufficient to increase swimming speed and% motile cells during late stage growth ( Figure 3C and E ), some other mutation(s) in P3 can also yield the same phenotype (compare late stage growth of solid red in Best Prices Online For Cheap Discount cropped trousers Blue Odeeh Outlet 2018 New Exclusive Sale Online cG9kKwfbr3
with sold black in Figure 3C , and solid red and solid black in High waist jeans Stella McCartney Buy Cheap Cheapest Price New Arrival Sale Online Best Store To Get For Sale bYdTdqz
). My hypothesis is further supposed by the observation that in Buy Cheap Factory Outlet Shanita sheer top Acne Studios 2018 Discount Classic Factory Outlet For Sale Outlet Excellent STT6gE
, the red line seems to show a much more drastic phenotype during early stages than the fliA mutant.

3) The writing is often confusing. For example, Figure 1A makes one believe that they are doing experiments, but Figure 1B and C give the impression of modeling. They do not lay out their model clearly (especially in the fifth paragraph of the main text where chemotaxis enters the game). Note that fitness (growth rate) can be quantified since it is constant during exponential phase. However, for chemotaxis, does population ratio change exponentially over time? In other words, would you get very different results if the duration of chemotaxis assay varies?

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Apply this action to the cluster resource.

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New in version 3.6.3.

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Shortcut for postcircumfix { } that quotes its argument using the same rules as the interpolating quote-words operator of the same name.

my % color = kiwi => " green " , banana => " yellow " , cherry => " red " ;
my $ fruit = " kiwi " ;
say % color « cherry " $ fruit " » . perl ; # OUTPUT:«("red","green")␤»

The call operator treats the invocant as a Callable and invokes it, using the expression between the parentheses as arguments.

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If you want your objects to respond to the call operator, implement a method CALL-ME .

The operator for calling one method, $invocant.method .

Technically, not a real operator; it's syntax special-cased in the compiler.

The operator to call a subroutine (with at least one positional argument), such as a method. The invocant will be bound to the first positional argument.

my sub f ( $ invocant ) { " Thearghasavalueof $ invocant " }
42 . f ;
# OUTPUT:«Thearghasavalueof42␤»
42 . ( -> $ invocant { " Thearghasavalueof $ invocant " } );
# OUTPUT:«Thearghasavalueof42␤»

A mutating method call . $invocant.=method desugars to $invocant = $invocant.method , similar to .

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