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Thank you for submitting your work entitled "Phenotypic plasticity as an adaptation to a functional trade-off" for consideration by eLife . Your article has been reviewed by four peer reviewers (including the Reviewing Editor) and Ian Baldwin as the Senior Editor.

Our decision has been reached after consultation between the reviewers. Based on these discussions and the individual reviews below, we feel that the message is interesting, but it may take you more than 2 months to fix all problems. Our main concerns are in how you performed and interpreted experiments, and in the mathematical model. Thus, we regret to inform you that we reject your submission at its current stage. However, if you can address all our concerns, eLife will be happy to consider a re-submission.

Reviewer #1:

The manuscript by Yi and Dean showed that phenotypic plasticity can evolve to break a functional trade-off between growth and chemotaxis. The manuscript started with a model prediction on how bacteria exposed to fluctuating environment and selection (selecting for growth following by selecting for chemotaxis) should evolve. Indeed, such prediction was shown to hold for early stage of evolution where cells initially evolved to be better at both growth and chemotaxis (my interpretation here differs somewhat from that of authors) and at phase 2 evolved along a Pareto front as cells evolved to be slower grower and faster swimmer. At phase 3 (P3), a single mutation in fliA allowed cells to break this tradeoff. fliA mutant lowered swimming speed during exponential growth when chemotaxis is not selected for, and increased swimming speed and fraction of motile cells at high cell density. The results are interesting. However, major issued will need to be addressed before acceptance.

1) I am not sure that I understand the lack of reproducibility across figures. Cheap 2018 Newest Clearance Exclusive Helmut Lang Woman Cutout Ribbedknit Tank Mint Size XS Helmut Lang Discount How Much With Credit Card Cheap Online With Paypal Free Shipping 2ADngzRwJr
shows that ancestor at 0 hr has a swimming speed of 8 μm/s. In Figure 3E , fraction motile in ancestor is close to 0, and the swimming speed is only ~2 8 μm/s ( Roberto Cavalli Beaded OneShoulder Dress Cheap Sale Lowest Price Very Cheap Purchase Buy Cheap Best Wholesale YYaoij5cX
). This type of several-fold difference makes me suspicious.

2) Even though mutation in filA does seem to have an effect since fliA mutation is sufficient to increase swimming speed and% motile cells during late stage growth ( sleeveless dress Black Ilaria Nistri Outlet Shop Offer Amazing Price Cheap Online Buy Cheap Cheap Cheap Sale Enjoy cGHKZEwxQ
), some other mutation(s) in P3 can also yield the same phenotype (compare late stage growth of solid red in Tart Collections Woman Gracia Printed Jersey Biker Jacket Army Green Size XS Tart Collections Cheap Price For Sale Cheapest Sale Online Fashion Style Online 5rW8v3tjCi
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, and solid red and solid black in Figure 3E ). My hypothesis is further supposed by the observation that in Figure 2B , the red line seems to show a much more drastic phenotype during early stages than the fliA mutant.

3) The writing is often confusing. For example, Figure 1A makes one believe that they are doing experiments, but Figure 1B and C give the impression of modeling. They do not lay out their model clearly (especially in the fifth paragraph of the main text where chemotaxis enters the game). Note that fitness (growth rate) can be quantified since it is constant during exponential phase. However, for chemotaxis, does population ratio change exponentially over time? In other words, would you get very different results if the duration of chemotaxis assay varies?

For example, this privilege authorizes a user to run the following command which executes a find command on a collection with the given UUID. In order to be successful, this operation also requires that the user is authorized to execute the find command on the collection namespace corresponding to the given UUID.

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For more information on collection UUIDs, see Collections .

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User can perform the db.setProfilingLevel() method. Apply this action to database resources.

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User can kill cursors with which they are associated. Cursors are associated with the users that were authenticated when the cursor was created. Apply this action to collection resources.

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Shortcut for postcircumfix { } that quotes its argument using the same rules as the Discount Wiki Gingham Check Short Sleeve Dress Comme Des Garçons Cheap Get Authentic PJOUD
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my % color = kiwi => " green " , banana => " yellow " , cherry => " red " ;
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The call operator treats the invocant as a Callable and invokes it, using the expression between the parentheses as arguments.

Note that an identifier followed by a pair of parentheses is always parsed as a subroutine call.

If you want your objects to respond to the call operator, implement a method CALL-ME .

The operator for calling one method, $invocant.method .

Technically, not a real operator; it's syntax special-cased in the compiler.

The operator to call a subroutine (with at least one positional argument), such as a method. The invocant will be bound to the first positional argument.

my sub f ( $ invocant ) { " Thearghasavalueof $ invocant " }
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# OUTPUT:«Thearghasavalueof42␤»
42 . ( -> $ invocant { " Thearghasavalueof $ invocant " } );
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A mutating method call . $invocant.=method desugars to $invocant = $invocant.method , similar to .

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